Klrb1b (Killer cell lectin-like receptor subfamily B member 1B allele B)

FEATURES

DESCRIPTION

Also known as KRBBB_RAT, Klrb1b, Nkrp1b, Nkrp1c. Receptor for CLEC2D/OCIL. Ligand-binding contributes to inhibition of cytotoxic natural killer (NK) cells. May mediate MHC class I-independent 'missing-self' recognition of allografts, tumor cells and virus-infected cells. Homodimer; disulfide-linked. Interacts with tyrosine kinase LCK. Binds PTPN6/SHP-1 in a phosphorylation-dependent manner.

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION

Klrb1b

Killer cell lectin-like receptor subfamily B member 1B allele B

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

Klrb1b

Molecular Synopsis