FEATURES

FAMILY

DESCRIPTION

Also known as TACY_STREQ, slo. A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol is required for binding to host membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus. Can be reversibly inactivated by oxidation. Homooligomeric pore complex of 35 to 50 subunits; when inserted in the host membrane.

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EXTERNAL LINKS

slo

Streptolysin O

ligandability Mutations

Molecular Synopsis
Structural Ligandability

slo

Structural Ligandability

Domains Chains

Distribution