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PLA1A (Phospholipase A1 member A)
FEATURES
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FAMILY
DESCRIPTION
Also known as PLA1A_HUMAN, PLA1A, NMD, PSPLA1. Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production.
Also known as PLA1A_HUMAN, PLA1A, NMD, PSPLA1. Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidi ...
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PLA1A

Phospholipase A1 member A

Mutations

FILTERS

Mutation(s) distribution

Mutations table

Study NameMutation TypeSeveritySeq. Cons. ScorePrediction scorePositionAmino acid changeTCGA Patient ID
Stomach (STAD) Missense variant MODERATE 14.8% 54.1% 2 Pro2Ser TCGA-VQ-A91D
Uterine carcinosarcoma (UCS) Missense variant MODERATE 1.1% 77.5% 4 Gly4Cys TCGA-ND-A4WC
Glioblastoma (GBM) Missense variant MODERATE 25.9% 74.2% 19 Leu19Val TCGA-06-0140
Uterine endometrial (UCEC) Missense variant MODERATE 0% 73.8% 28 Pro28His TCGA-EO-A22R
Lung squamous (LUSC) Missense variant MODERATE 46.7% 70% 48 Asp48His TCGA-90-7769
Uterine endometrial (UCEC) Missense variant MODERATE 46.7% 74.6% 48 Asp48Tyr TCGA-B5-A3FA
Cervical (CESC) Missense variant MODERATE 46.7% 56.6% 48 Asp48Asn TCGA-EK-A2PG
Colon (COAD) Missense variant MODERATE 12.5% 59% 48 Asp48Ala TCGA-AZ-4315
Lung squamous (LUSC) Missense variant MODERATE 100% 90.8% 52 Gln52Pro TCGA-37-4135
Uterine endometrial (UCEC) Missense variant MODERATE 100% 93.3% 54 Leu54Ile TCGA-EO-A22R