PDX1 (Probable pyridoxal 5'-phosphate synthase subunit PDX1)

FEATURES

FAMILY

DESCRIPTION

Also known as PDX1_HEVBR, PDX1, ER1. Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by PDX2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers.

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EXTERNAL LINKS

PDX1

Probable pyridoxal 5'-phosphate synthase subunit PDX1

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

PDX1

Molecular Synopsis