OMT2 (Tricetin 3', 4', 5'-O-trimethyltransferase)

FEATURES

FAMILY

Cation-independent O-methyltransferase family

DESCRIPTION

Also known as FOMT2_WHEAT, OMT2. Flavonoid B-ring-specific O-methyltransferase with a preference for flavones > dihydroflavones > flavonols that possess at least two B-ring hydroxyl groups. Active with tricetin, 5-hydroxyferulic acid, luteolin, quercitin, eriodictyol, quercetagetin, taxifolin, gossypetin and myricetin. No activity with naringenin, apigenin, kaempferol, 7, 8-dihydroxy- or 5, 7, 8-trihydroxy flavones, chlorogenic acid, gallic acid or daphnetin. Catalyzes the sequential O-methylation of tricetin via 3'-O-methyltricetin, 3', 5'-O-methyltricetin to 3', 4', 5'-O-trimethyltricetin. May also be involved in S lignin biosynthesis. Homodimer. The monomer is fully active and dimerization is not required for sequential methylation.

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EXTERNAL LINKS

OMT2

Tricetin 3', 4', 5'-O-trimethyltransferase

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

OMT2

Molecular Synopsis