rept (RuvB-like helicase 2)

FEATURES

FAMILY

DESCRIPTION

Also known as RUVB2_DROPS, rept. Acts as a transcriptional coactivator in Wg signaling caused by altered arm signaling. Pont and rept interfere antagonistically with nuclear arm signaling function, and are required to enhance or reduce arm activity, respectively. Also an essential cofactor for the normal function of Myc; required for cellular proliferation and growth (By similarity)., Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Forms homohexameric rings. May form a dodecamer with rept made of two stacked hexameric rings. Component of the chromatin remodeling Ino80 complex (By similarity).

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EXTERNAL LINKS

rept

RuvB-like helicase 2

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

rept

Molecular Synopsis