MYO6 (Unconventional myosin-VI)

FEATURES

FAMILY

DESCRIPTION

Also known as MYO6_PIG, MYO6. Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (By similarity). Has slow rate of actin-activated ADP release due to weak ATP binding (PubMed:15944696). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (PubMed:16917816). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway (By similarity). Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells (By similarity). May act as a regulator of F-actin dynamics (PubMed:7929586). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (By similarity). May play a role in transporting DAB2 from the plasma membrane to specific cellular targets (By similarity). May play a role in the extension and network organization of neurites (By similarity). Required for structural integrity of inner ear hair cells (By similarity). Modulates RNA polymerase II-dependent transcription (By similarity). Homodimer; dimerization seems to implicate the unfolding of the three-helix bundle region creating an additional calmodulin binding site, and cargo binding (PubMed:25159143, PubMed:19664948). Component of the DISP/DOCK7-induced septin displacement complex, at least composed of DOCK7, LRCH3 and MYO6 (By similarity). Able to function as a monomer under specific conditions in vitro (By similarity). Forms a complex with CFTR and DAB2 in the apical membrane of epithelial cells (By similarity). Binding to calmodulin through a unique insert, not found in other myosins, located in the neck region between the motor domain and the IQ domain appears to contribute to the directionality reversal (PubMed:15037754). This interaction occurs only if the C-terminal lobe of calmodulin is occupied by calcium (PubMed:12682054, PubMed:15037754). Interaction with F-actin/ACTN1 occurs only at the apical brush border domain of the proximal tubule cells (PubMed:7929586). Interacts with DAB2 (By similarity). In vitro, the C-terminal globular tail binds a C-terminal region of DAB2 (By similarity). Interacts with CFTR (By similarity). Interacts with OPTN (By similarity). Interacts with CABP5 (By similarity).

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EXTERNAL LINKS

MYO6

Unconventional myosin-VI

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

MYO6

Molecular Synopsis