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DOT1 (Histone-lysine N-methyltransferase, H3 lysine-79 specific)
FEATURES
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FAMILY
DESCRIPTION
Also known as DOT1_COCIM, DOT1. Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones (By similarity).
Also known as DOT1_COCIM, DOT1. Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free his ... More
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DOT1

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Molecular Synopsis