FEATURES

FAMILY

DESCRIPTION

Also known as KCA10_HUMAN, KCNA10. Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP. Homotetramer. Interacts with KCN4B/POMP. Interaction with KCN4B/POMP is necessary for the modulation of channel activity by cAMP.

... More

EXTERNAL LINKS

KCNA10

Potassium voltage-gated channel subfamily A member 10

ligandability Mutations

KCNA10

Molecular Synopsis