FEATURES

DESCRIPTION

Also known as TAB1_HUMAN, TAB1, MAP3K7IP1. May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis. Interacts with XIAP and BIRC7 (PubMed:17560374, PubMed:11865055). Interacts with TRAF6 and MAP3K7; during IL-1 signaling (PubMed:8638164, PubMed:10094049, PubMed:11323434). Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2 (PubMed:11460167).

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION
PhosphoSitePlus

TAB1

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

ligandability Mutations

TAB1

Molecular Synopsis