FEATURES

FAMILY

DESCRIPTION

Also known as KS6A2_HUMAN, RPS6KA2, MAPKAPK1C, RSK3. Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity). Interacts with FBXO5; cooperate to induce the metaphase arrest of early blastomeres; increases and stabilizes interaction of FBXO5 with CDC20 (By similarity).

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EXTERNAL LINKS

RPS6KA2

Ribosomal protein S6 kinase alpha-2

ligandability Mutations

RPS6KA2

Molecular Synopsis