FEATURES

FAMILY

DESCRIPTION

Also known as CDK10_HUMAN, CDK10. Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) (PubMed:24218572). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling (PubMed:27104747). Heterodimer with CCNQ, the interaction is required for kinase activity. Interacts with ETS2. Interacts with PRK2 (PubMed:27104747).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CDK10

Cyclin-dependent kinase 10

CDK10

Molecular Synopsis