FEATURES

FAMILY

DESCRIPTION

Also known as SHPRH_HUMAN, SHPRH, KIAA2023. E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'. Homodimer. Interacts with HLTF, PCNA, UBE2N and RAD18.

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION
PhosphoSitePlus

SHPRH

E3 ubiquitin-protein ligase SHPRH

ligandability Mutations

SHPRH

Molecular Synopsis