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SCN5A (Sodium channel protein type 5 subunit alpha)
FEATURES
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FAMILY
DESCRIPTION
Also known as SCN5A_HUMAN, SCN5A. This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:1309946, PubMed:21447824, PubMed:25370050, PubMed:23420830, PubMed:23085483, PubMed:26279430, PubMed:26392562, PubMed:26776555). It is a tetrodotoxin-resistant Na(+) channel isoform (PubMed:1309946). This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels (PubMed:19074138). Interacts with the PDZ domain of the syntrophin SNTA1, SNTB1 and SNTB2 (By similarity). Interacts with NEDD4, NEDD4L, WWP2 and GPD1L (PubMed:15217910, PubMed:15548568, PubMed:19666841). Interacts with CALM (PubMed:21167176, PubMed:22705208, PubMed:25370050). Interacts with FGF13; the interaction is direct and FGF13 may regulate SNC5A density at membranes and function (PubMed:21817159, PubMed:22705208, PubMed:26392562). May also interact with FGF12 and FGF14 (PubMed:26392562). Interacts with the spider Jingzhaotoxin-I (AC P83974, AC B1P1B7, AC B1P1B8) (PubMed:26721415). Interacts with ANK3 (PubMed:15579534).
Also known as SCN5A_HUMAN, SCN5A. This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradi ...
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SCN5A

Sodium channel protein type 5 subunit alpha

Expression

StudyTumor samplesMaxQ3Q2Q1MinNormal samplesMaxQ3Q2Q1MinLog2 (T vs N)
Adrenocortical (ACC) 77 1.67 0.73 0.30 -0.32 -0.00 126 0.93 0.35 0.19 0.02 -0.00 0.11
Bladder (BLCA) 406 2.26 1.15 0.71 0.36 -0.00 9 1.31 1.30 1.16 0.58 0.37 -0.45
Breast (BRCA) 1067 1.45 0.41 0.18 -0.40 -0.00 178 1.32 0.83 0.67 0.46 -0.06 -0.49
Cervical (CESC) 297 1.88 0.51 0.30 0.08 -0.00 10 1.65 1.54 1.30 1.18 0.72 -1.00
Cholangiocarcinoma (CHOL) 36 1.34 0.58 0.15 0.01 -0.15 0
Colon (COAD) 443 1.74 0.44 0.21 -0.69 -0.00 166 1.18 0.77 0.59 0.46 -0.09 -0.38
B-cell lymphoma (DLBC) 42 1.84 0.15 -0.35 -0.13 -0.00 337 2.11 1.05 0.48 0.07 -0.01 -0.83
Esophageal (ESCA) 142 1.42 0.57 0.31 0.09 -0.01 271 1.04 0.40 0.31 0.18 -0.00 -0.00
Glioblastoma (GBM) 160 1.46 0.47 0.25 0.07 -0.01 214 1.08 0.42 0.29 0.19 -0.01 -0.04
Head and neck (HNSC) 432 1.99 0.91 0.46 0.13 -0.00 55 2.16 0.43 0.30 0.16 -0.02 0.16