FEATURES

FAMILY

DESCRIPTION

Also known as CDK13_HUMAN, CDK13, CDC2L, CDC2L5, CHED, KIAA1791. Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. Interacts with CCNL1 and CCNL2 (By similarity). Interacts with CCNK. Interacts with C1QBP.

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EXTERNAL LINKS

CDK13

Cyclin-dependent kinase 13

ligandability Mutations

CDK13

Molecular Synopsis