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RIN1 (Ras and Rab interactor 1)
FEATURES
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FAMILY
DESCRIPTION
Also known as RIN1_HUMAN, RIN1. Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. Interacts with the GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). This interaction prevents the association between RAF1 and Ras. Interacts with 14-3-3 proteins YWHAB, YWHAE and YWHAZ when phosphorylated on Ser-351. Interacts with the SH3 domain of ABL1 and ABL2. Interacts with RAB5A. The interaction with Ras is probably regulated and antagonized by the interaction with 14-3-3 proteins. The interaction with 14-3-3 proteins is regulated by phosphorylation on Ser-351.
Also known as RIN1_HUMAN, RIN1. Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodel ...
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RIN1

Ras and Rab interactor 1

Mutations

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Mutation(s) distribution

Mutations table

Study NameMutation TypeSeveritySeq. Cons. ScorePrediction scorePositionAmino acid changeTCGA Patient ID
Bladder (BLCA) Missense variant MODERATE 97.8% 17.8% 783 Glu783Gln TCGA-DK-A1AC
Stomach (STAD) Missense variant MODERATE 0% 30.2% 779 Arg779Gln TCGA-BR-4292
Stomach (STAD) Missense variant MODERATE 0% 30.2% 779 Arg779Gln TCGA-BR-8296
Stomach (STAD) Missense variant MODERATE 75.4% 14.8% 779 Arg779Trp TCGA-BR-8363
Bladder (BLCA) Missense variant MODERATE 0% 29.5% 756 Ala756Gly TCGA-K4-A6FZ
Bladder (BLCA) Missense variant MODERATE 0% 35.4% 753 Glu753Gln TCGA-DK-A1AC
Colon (COAD) Missense variant MODERATE 0% 35.4% 753 Glu753Gln TCGA-A6-6651
Lung adenocarcinoma (LUAD) Missense variant MODERATE 0% 28.2% 752 Ser752Phe TCGA-44-6776
Breast (BRCA) Missense variant MODERATE 0% 10% 749 Arg749Trp TCGA-E9-A1RF
Uterine endometrial (UCEC) Missense variant MODERATE 0% 10% 749 Arg749Trp TCGA-B5-A0JY