FEATURES

FAMILY

DESCRIPTION

Also known as CRFR2_HUMAN, CRHR2, CRF2R, CRH2R. G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Monomer. Interacts (via N-terminal extracellular domain) with CRF, UCN, UCN2 and UCN3. Has highest affinity for UCN, and considerably lower affinity for CRF, UNC2 and UCN3.

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EXTERNAL LINKS

CRHR2

Corticotropin-releasing factor receptor 2

ligandability Mutations

CRHR2

Molecular Synopsis