FEATURES

FAMILY

DESCRIPTION

Also known as NDK3_HUMAN, NME3. Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis.

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION
PhosphoSitePlus

NME3

Nucleoside diphosphate kinase 3

ligandability Mutations

NME3

Molecular Synopsis