FEATURES

FAMILY

DESCRIPTION

Also known as MP2K5_HUMAN, MAP2K5, MEK5, MKK5, PRKMK5. Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. Interacts with PARD6A, MAP3K3 and MAPK7. Forms a complex with SQSTM1 and PRKCZ or PRKCI (By similarity).

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION
PhosphoSitePlus

MAP2K5

Dual specificity mitogen-activated protein kinase kinase 5

ligandability Mutations

MAP2K5

Molecular Synopsis