FEATURES

FAMILY

class V-like SAM-binding methyltransferase superfamily

DESCRIPTION

Also known as PRDM2_HUMAN, PRDM2, KMT8, RIZ. S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. Binds to the retinoblastoma protein (RB). Interacts with GATA3.

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION
PhosphoSitePlus

PRDM2

PR domain zinc finger protein 2

ligandability Mutations

PRDM2

Molecular Synopsis