FEATURES

DESCRIPTION

Also known as KLRB1_HUMAN, KLRB1, CLEC5B, NKRP1A. Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1, 3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. Homodimer; disulfide-linked. Interacts with acid sphingomyelinase/SMPD1.

EXTERNAL LINKS

KLRB1

Killer cell lectin-like receptor subfamily B member 1

KLRB1

Molecular Synopsis