FEATURES

FAMILY

aspartyl/asparaginyl beta-hydroxylase family

DESCRIPTION

Also known as ASPH_HUMAN, ASPH, BAH. specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins., membrane-bound Ca(2+)-sensing protein, which is a structural component of the ER-plasma membrane junctions. Isoform 8 regulates the activity of Ca(+2) released-activated Ca(+2) (CRAC) channels in T-cells. Monomer (By similarity). Isoform 8 interacts with ORAI1 and STIM1. Isoform 4 interacts with CASQ2.

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION
PhosphoSitePlus

ASPH

Aspartyl/asparaginyl beta-hydroxylase

ligandability Mutations

ASPH

Molecular Synopsis