trm12 (tRNA wybutosine-synthesizing protein 2)

FEATURES

FAMILY

DESCRIPTION

Also known as TYW2_SCHPO, trm12, tyw2. S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86 (By similarity).

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EXTERNAL LINKS

trm12

tRNA wybutosine-synthesizing protein 2

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

trm12

Molecular Synopsis