MST1R logo
MST1R (Macrophage-stimulating protein receptor)
FEATURES
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FAMILY
DESCRIPTION
Also known as RON_HUMAN, MST1R, PTK8, RON. Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand. Heterodimer of an alpha chain and a beta chain which are disulfide linked. Binds PLXNB1. Associates with and is negatively regulated by HYAL2. Interacts when phosphorylated with downstream effectors including PIK3R1, PCLG1, GRB2 and GAB1. Interacts with integrin beta1/ITGB1 in a ligand-independent fashion.
Also known as RON_HUMAN, MST1R, PTK8, RON. Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellu ...
MST1R logo

MST1R

Macrophage-stimulating protein receptor

Interactome

MST1R is reported in 4 pathways.
Provide LogoProviderPathway sizePathway name
a6b1 and a6b4 Integrin signaling logo
NCI Curated Human Pathways from PID (final); 27-Jul-2015 46 a6b1 and a6b4 Integrin signaling
amb2 Integrin signaling logo
NCI Curated Human Pathways from PID (final); 27-Jul-2015 32 amb2 Integrin signaling
Alpha6Beta4Integrin logo
NetPath 12/2011 74 Alpha6Beta4Integrin
Signaling by MST1 logo
Reactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017 5 Signaling by MST1