FEATURES

FAMILY

adenylyl cyclase class-4/guanylyl cyclase family

DESCRIPTION

Also known as GCYB1_HUMAN, GUCY1B1, GUC1B3, GUCSB3, GUCY1B3. Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP. The active enzyme is formed by a heterodimer of an alpha and a beta subunit. Heterodimer with GUCY1A1 (PubMed:1352257, PubMed:23505436, PubMed:24669844). Can also form inactive homodimers in vitro (PubMed:23505436, PubMed:24669844).

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION
PhosphoSitePlus

GUCY1B1

Guanylate cyclase soluble subunit beta-1

ligandability Mutations

GUCY1B1

Molecular Synopsis