FEATURES

FAMILY

DESCRIPTION

Also known as NAAA_HUMAN, NAAA, ASAHL, PLT. Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine (PubMed:15655246, PubMed:17980170, PubMed:18793752, PubMed:30301806, PubMed:22825852). Also exhibits weak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine (PubMed:15655246). Heterodimer of an alpha and a beta subunit, produced by autocatalytic cleavage.

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EXTERNAL LINKS

NAAA

N-acylethanolamine-hydrolyzing acid amidase

ligandability Mutations

NAAA

Molecular Synopsis