FEATURES

FAMILY

inositol 1,4,5-trisphosphate 5-phosphatase type II family

DESCRIPTION

Also known as OCRL_HUMAN, OCRL, OCRL1. Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4, 5-bisphosphate (PtdIns(4, 5)P2) and phosphatidylinositol-3, 4, 5-bisphosphate (PtdIns(3, 4, 5)P3), with the greatest catalytic activity towards PtdIns(4, 5)P2 (PubMed:7761412, PubMed:15474001, PubMed:9430698, PubMed:10764818). Able also to hydrolyzes the 4-phosphate of inositol 1, 4, 5-trisphosphate and of inositol 1, 3, 4, 5-tetrakisphosphate (PubMed:7761412, PubMed:25869668). Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4, 5-bisphosphate that is associated with endosomes (PubMed:21971085). Involved in primary cilia assembly (PubMed:22228094, PubMed:22543976). Acts as a regulator of phagocytosis, hydrolyzing PtdIns(4, 5)P2 to promote phagosome closure, through attenuation of PI3K signaling (PubMed:22072788). Interacts with APPL1, FAM109A/SES1 and FAM109B/SES2; APPL1-binding and FAM109A-binding are mutually exclusive. Interacts with clathrin heavy chain. Interacts with several Rab GTPases, at least RAB1B, RAB5A, RAB6A, RAB8A and RAB31; these interactions may play a dual role in targeting OCRL to the specific membranes and stimulating the phosphatase activity. Interaction with RAB8A modulates OCRL recruitment to cilia. Interacts with INPP5F (PubMed:25869668).

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EXTERNAL LINKS

OCRL

Inositol polyphosphate 5-phosphatase OCRL

ligandability Mutations

OCRL

Molecular Synopsis