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whiB4 (Transcriptional regulator WhiB4)
FEATURES
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FAMILY
DESCRIPTION
Also known as WHIB4_MYCTU, whiB4. Redox-responsive transcriptional regulator that regulates a set of genes involved in protection against environmental stresses encountered during infection. The loss of the O(2) and NO-responsive 4Fe-4S cluster and subsequent redox modifications of Cys residue thiols (possibly by disulfide bond formation) may activate its role in gene regulation. The thiol-oxidized apo-form binds in a sequence non-specific manner to GC-rich DNA, probably in the minor groove. Represses transcription of a number of genes including itself. The reduced apo-form and holo-form do not bind DNA. The apo-form can act as protein disulfide reductase. Homodimer in the presence of reducing agents (PubMed:17302817); the oxidized apo-form makes dimers and trimers while the redeced apo-form does not (PubMed:22780904). Upon over expression in aerobically grown M.smegmatis, apo-WhiB4 forms trimers held together by disulfide bonds.
Also known as WHIB4_MYCTU, whiB4. Redox-responsive transcriptional regulator that regulates a set of genes involved in protection against environmental stresses encountered during infection. The loss of the O(2) and NO-responsive 4Fe-4S cluster and subsequent redox modifications of Cys residue thiols (possibly by disulfide bond formation) may activ ... More
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whiB4

Transcriptional regulator WhiB4

Molecular Synopsis