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Smc3 (Structural maintenance of chromosomes protein 3)
FEATURES
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FAMILY
DESCRIPTION
Also known as SMC3_RAT, Smc3, Bam, Bmh, Cspg6, Smc3l1. Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement (By similarity). Forms a heterodimer with SMC1A or SMC1B in cohesin complexes. Cohesin complexes are composed of the SMC1 (SMC1A or meiosis-specific SMC1B) and SMC3 heterodimer attached via their SMC hinge domain, RAD21 which link them, and one STAG protein (STAG1, STAG2 or STAG3), which interacts with RAD21. Also found in meiosis-specific cohesin complexes. Found in a complex with SMC1A, CDCA5 and RAD21, PDS5A/SCC-112 and PDS5B/APRIN. Interacts with MXI1, MXD3 and MXD4. Interacts with NUMA1, and forms a ternary complex with KIF3B and KIFAP3, suggesting a function in tethering the chromosomes to the spindle pole and a function in chromosome movement. Interacts with PDS5A and WAPL; regulated by SMC3 acetylation. Interacts (via SMC hinge domain) with KIAA1328 (via N- and C-terminal domains). Interacts with DDX11, RPGR and STAG3. Found in a cohesin complex with SMC1A, RAD21 and STAG1. The SMC1A-SMC3 heterodimer interacts with the NIPBL-MAU2 heterodimer (By similarity). Interacts with SYCP2 (PubMed:10652260).
Also known as SMC3_RAT, Smc3, Bam, Bmh, Cspg6, Smc3l1. Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids t ... More
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Smc3

Structural maintenance of chromosomes protein 3

Molecular Synopsis