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Cacna1a (Voltage-dependent P/Q-type calcium channel subunit alpha-1A)
FEATURES
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FAMILY
DESCRIPTION
Also known as CAC1A_MOUSE, Cacna1a, Caca1a, Cach4, Cacn3, Cacnl1a4, Ccha1a. Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by the spider omega-agatoxin-IVA (AC P54282) (By similarity). They are however insensitive to dihydropyridines (DHP). Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts with CABP1 (By similarity).Interacts with the spider omega-agatoxin-IVA (AC P30288) (By similarity).
Also known as CAC1A_MOUSE, Cacna1a, Caca1a, Cach4, Cacn3, Cacnl1a4, Ccha1a. Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell divisi ... More
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Cacna1a

Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Molecular Synopsis