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crk (Adapter molecule crk)
FEATURES
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FAMILY
DESCRIPTION
Also known as CRK_XENLA, crk. Required for apoptosis in Xenopus egg extracts. May mediate attachment-induced mapk8 activation, membrane ruffling and cell motility in a Rac-dependent manner. May regulate the efna5-epha3 signaling (By similarity). Interacts with abl, c3g, sos, map4k1, mapk8 and dock1 via its first SH3 domain. Interacts with bcar1, cbl, pxn and gab1 via its SH2 domain upon stimulus-induced tyrosine phosphorylation. Interacts with several tyrosine-phosphorylated growth factor receptors such as egfr, pdgfr and insr via its SH2 domain (By similarity).
Also known as CRK_XENLA, crk. Required for apoptosis in Xenopus egg extracts. May mediate attachment-induced mapk8 activation, membrane ruffling and cell motility in a Rac-dependent manner. May regulate the efna5-epha3 signaling (By similarity). Interacts with abl, c3g, sos, map4k1, mapk8 and dock1 via its first SH3 domain. Interacts with bcar1, cb ... More
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crk

Adapter molecule crk

Molecular Synopsis