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(Rho-elapitoxin-Da1b)
FEATURES
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FAMILY
DESCRIPTION
Also known as 3SI1B_DENAN. Non-competitive antagonist of alpha-2 adrenergic receptors (ADRA2) in smooth muscles, and partial antagonist of D3 dopamine receptors (DRD3) (inhibits 25% of methylspiperone binding to this receptor) (PubMed:20659106). Also shows a low antagonism on D2 dopamine receptors (DRD2) (short isoform) (PubMed:24793485). Shows high affinity to adrenergic receptors (Ki=14 nM (ADRA2A), Ki=73 nM (ADRA2B), and Ki=38 nM (ADRA2C)) (PubMed:20659106). Increases heart rate and blood catecholamine concentrations (PubMed:21419153).
Also known as 3SI1B_DENAN. Non-competitive antagonist of alpha-2 adrenergic receptors (ADRA2) in smooth muscles, and partial antagonist of D3 dopamine receptors (DRD3) (inhibits 25% of methylspiperone binding to this receptor) (PubMed:20659106). Also shows a low antagonism on D2 dopamine receptors (DRD2) (short isoform) (PubMed:24793485). Shows hig ... More
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Rho-elapitoxin-Da1b

Molecular Synopsis