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BTG2 (Protein BTG2)
FEATURES
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FAMILY
DESCRIPTION
Also known as BTG2_HUMAN, BTG2, PC3. Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth. Interacts with PRKCABP (By similarity). Interacts with CNOT7 and CNOT8; indicative for an association with the CCR4-NOT complex. Interacts with PIN1, inducing mitochondrial depolarization.
Also known as BTG2_HUMAN, BTG2, PC3. Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the grow ...
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BTG2

Protein BTG2

Copy number variation

DiseaseSignal Cell linesGain Cell linesAvg. ampLoss Cell linesAvg. lossNo-signal Cell linesAvg. change
cancer 0 0 0 147 1.13
NS 0 0 0 153 1.13
carcinoma 1 1 2.62 0 551 1.12
haematopoietic_neoplasm 0 0 0 63 1.14
leukaemia 0 0 0 84 1.11
lymphoid_neoplasm 2 2 2.48 0 133 1.12
glioma 0 0 0 52 1.07
malignant_melanoma 0 0 0 56 1.14
melanoma 0 0 0 43 1.09
glioblastoma 0 0 0 2 1.26

Cell lines

Cell lineSignalCopy numberAvg. genome ploidyAmplificationDiseaseTissue
22Rv-1 No signal 3 2.04 1.47 cancer, NS, carcinoma prostate
5637 No signal 3 2.99 1.00 cancer, carcinoma bladder, urinary_tract
639-V No signal 2 2.41 0.83 cancer, carcinoma bladder, ureter, urinary_tract
647-V No signal 3 2.50 1.20 cancer, carcinoma bladder, urinary_tract
697 No signal 3 1.98 1.51 haematopoietic_neoplasm, leukaemia, lymphoid_neoplasm blood_bone_marrow, haematopoietic_and_lymphoid_tissue
769-P No signal 3 1.97 1.52 carcinoma kidney
786-0 No signal 4 3.82 1.05 cancer, carcinoma kidney
8-MG-BA No signal 2 2.20 0.91 glioma brain, central_nervous_system
8305C No signal 2 3.09 0.65 carcinoma thyroid
8505C No signal 3 3.00 1.00 carcinoma thyroid