FEATURES

FAMILY

DESCRIPTION

Also known as RAB14_HUMAN, RAB14. Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion. Interacts with KIF16B (By similarity). Interacts with ZFYVE20.

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EXTERNAL LINKS

RAB14

Ras-related protein Rab-14

ligandability Mutations

RAB14

Molecular Synopsis