FEATURES

FAMILY

DESCRIPTION

Also known as TPIS_HUMAN, TPI1, TPI. Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis., It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. Homodimer.

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION
PhosphoSitePlus

TPI1

Triosephosphate isomerase

ligandability Mutations

TPI1

Molecular Synopsis