FEATURES

FAMILY

calcium channel subunit alpha-2/delta family

DESCRIPTION

Also known as CA2D1_HUMAN, CACNA2D1, CACNL2A, CCHL2A, MHS3. The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity). Dimer formed of alpha-2-1 and delta-1 chains; disulfide-linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio (By similarity).

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EXTERNAL LINKS

CACNA2D1

Voltage-dependent calcium channel subunit alpha-2/delta-1

ligandability Mutations

CACNA2D1

Molecular Synopsis