METAP1 logo
METAP1 (Methionine aminopeptidase 1)
FEATURES
Loading...
Loading...
FAMILY
DESCRIPTION
Also known as MAP11_HUMAN, METAP1, KIAA0094. Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle. Associates with the 60S ribosomal subunit of the 80S translational complex.
Also known as MAP11_HUMAN, METAP1, KIAA0094. Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle. Associates with ...
METAP1 logo

METAP1

Methionine aminopeptidase 1

Germline Genetics

Summary of germline evidence for METAP1 and cancer

  • Ensembl Gene ID: ENSG00000164024
  • Ensembl Transcript ID/s: ENST00000296411
  • Entrez Gene ID: 23173
  • HGNC Gene Symbol: METAP1

Genome-wide association studies

METAP1 maps to cancer-SNP associations according to the following annotations:

SNPLocusPosition (b37)Risk alleleRAFP-valueEffect sizeCICancerPMIDCatalogTADLSDEPICT
614_rs971074 4q23 100341861 rs971074-G NR 9E-17 1.33 [1.25-1.43] Oral cavity and pharyngeal cancer 21437268 https://www.ebi.ac.uk/gwas/search?query=rs971074 4:99020000-100500000 r2>0.2 (4:99927044-100662452) -
1071_rs1229984 4q23 100239319 rs1229984-G 0.94 2E-15 1.7898692 Oral cavity and pharyngeal cancer 27749845 https://www.ebi.ac.uk/gwas/search?query=rs1229984 4:99020000-100500000 r2>0.3 (4:99751794-100712034) -
613_rs1229984 4q23 100239319 rs1229984-T 0.94 1E-20 1.56 [1.41-1.69] Oral cavity and pharyngeal cancer 21437268 https://www.ebi.ac.uk/gwas/search?query=rs1229984 4:99020000-100500000 r2>0.3 (4:99751794-100712034) -
1075_rs1229984 4q23 100239319 rs1229984-G 0.94 1E-9 1.7436792 NR Oral cavity cancer 27749845 https://www.ebi.ac.uk/gwas/search?query=rs1229984 4:99020000-100500000 r2>0.3 (4:99751794-100712034) -
599_rs1229984 4q23 100239319 rs1229984-G NR 8E-24 1.79 [1.69-1.88] Esophageal cancer 19698717 https://www.ebi.ac.uk/gwas/search?query=rs1229984 4:99020000-100500000 r2>0.3 (4:99751794-100712034) -
1195_rs1229984 4q23 100239319 rs1229984-G 0.94014554632151 9E-9 1.832173 Oropharynx cancer 27749845 https://www.ebi.ac.uk/gwas/search?query=rs1229984 4:99020000-100500000 r2>0.3 (4:99751794-100712034) -