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METAP2 (Methionine aminopeptidase 2)
FEATURES
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FAMILY
DESCRIPTION
Also known as MAP2_HUMAN, METAP2, MNPEP, P67EIF2. Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo., Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis. Interacts strongly with the eIF-2 gamma-subunit EIF2S3 (By similarity). Binds EIF2S1 at low magnesium concentrations.
Also known as MAP2_HUMAN, METAP2, MNPEP, P67EIF2. Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is ...
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METAP2

Methionine aminopeptidase 2

Germline Genetics

Summary of germline evidence for METAP2 and cancer

  • Ensembl Gene ID: ENSG00000111142
  • Ensembl Transcript ID/s: ENST00000261220; ENST00000323666; ENST00000546753
  • Entrez Gene ID: 10988
  • HGNC Gene Symbol: METAP2

Genome-wide association studies

METAP2 maps to cancer-SNP associations according to the following annotations:

SNPLocusPosition (b37)Risk alleleRAFP-valueEffect sizeCICancerPMIDCatalogTADLSDEPICT
715_rs17356907 12q22 96027759 rs17356907-A 0.7 1E-39 1.098901 [1.08-1.11] (Oncoarray) Breast cancer 29059683 https://www.ebi.ac.uk/gwas/search?query=rs17356907 12:95380000-96420000 - -
370_rs17356907 12q22 96027759 rs17356907-A 0.7 7E-21 1.098901 [1.08-1.11] Breast cancer 25751625 https://www.ebi.ac.uk/gwas/search?query=rs17356907 12:95380000-96420000 - -
866_rs17356907 12q22 96027759 rs17356907-A 0.7 2E-22 1.1 [1.08-1.12] Breast cancer 23535729 https://www.ebi.ac.uk/gwas/search?query=rs17356907 12:95380000-96420000 - -
2671_rs17356907 12q22 96027759 rs17356907-A 0.7 2E-8 1.0638298 [1.03-1.1] (Oncoarray) Breast cancer (estrogen-receptor negative) 29058716 https://www.ebi.ac.uk/gwas/search?query=rs17356907 12:95380000-96420000 - -
2287_rs17356907 12q22 96027759 rs17356907-A 0.7 1E-39 1.098901 [1.08-1.11] (Oncoarray) Breast cancer 29059683 https://www.ebi.ac.uk/gwas/search?query=rs17356907 12:95380000-96420000 - -
2250_rs17356907 12q22 96027759 rs17356907-A 0.7 2E-8 1.0638298 [1.03-1.1] (Oncoarray) Breast cancer (estrogen-receptor negative) 29058716 https://www.ebi.ac.uk/gwas/search?query=rs17356907 12:95380000-96420000 - -
2028_chr12:96027759 96421537 chr12:96027759-G 0.2985 1E-39 0.0898 [0.076-0.103] unit decrease Breast cancer 29059683 https://www.ebi.ac.uk/gwas/search?query=rs888410431 12:95380000-96420000 - -
2449_chr12:96027759 96421537 chr12:96027759-G 0.2985 1E-39 0.0898 [0.076-0.103] unit decrease Breast cancer 29059683 https://www.ebi.ac.uk/gwas/search?query=rs888410431 12:95380000-96420000 - -