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METAP2 (Methionine aminopeptidase 2)
FEATURES
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FAMILY
DESCRIPTION
Also known as MAP2_HUMAN, METAP2, MNPEP, P67EIF2. Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo., Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis. Interacts strongly with the eIF-2 gamma-subunit EIF2S3 (By similarity). Binds EIF2S1 at low magnesium concentrations.
Also known as MAP2_HUMAN, METAP2, MNPEP, P67EIF2. Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is ...
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METAP2

Methionine aminopeptidase 2

Expression

StudyTumor samplesMaxQ3Q2Q1MinNormal samplesMaxQ3Q2Q1MinLog2 (T vs N)
Adrenocortical (ACC) 77 2.47 2.32 2.24 2.17 1.95 126 2.27 2.17 2.12 2.07 -0.09 0.11
Bladder (BLCA) 406 2.70 2.15 2.08 1.99 1.67 9 2.04 2.03 2.00 1.93 1.87 0.07
Breast (BRCA) 1067 2.52 2.09 2.03 1.96 1.49 178 2.19 2.01 1.96 1.91 1.81 0.07
Cervical (CESC) 297 2.47 2.15 2.08 2.02 1.70 10 2.06 2.05 2.00 2.00 1.91 0.08
Cholangiocarcinoma (CHOL) 36 2.39 2.15 2.05 1.98 1.77 0
Colon (COAD) 443 2.58 2.22 2.14 2.07 1.68 166 2.20 1.98 1.91 1.87 -0.09 0.24
B-cell lymphoma (DLBC) 42 2.77 2.40 2.28 2.15 1.98 337 2.27 1.81 1.71 1.60 1.11 0.57
Esophageal (ESCA) 142 2.36 2.16 2.05 1.97 1.81 271 2.24 2.08 2.04 1.96 -0.09 0.02
Glioblastoma (GBM) 160 2.46 2.16 2.10 2.04 1.79 214 2.08 1.92 1.88 1.84 -0.09 0.22
Head and neck (HNSC) 432 2.45 2.25 2.18 2.10 1.88 55 2.18 1.97 1.91 1.85 1.77 0.28