CDK8 logo
CDK8 (Cyclin-dependent kinase 8)
FEATURES
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FAMILY
DESCRIPTION
Also known as CDK8_HUMAN, CDK8. Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation. Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed by CCNC/CDK8 also associates with the large subunit of RNA polymerase II. Interacts with CTNNB1, GLI3 and MAML1.
Also known as CDK8_HUMAN, CDK8. Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promot ...
CDK8 logo

CDK8

Cyclin-dependent kinase 8

Interactome

CDK8 is reported in 13 pathways.
Provide LogoProviderPathway sizePathway name
AKT(PKB)-Bad signaling ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ) logo
INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011 173 AKT(PKB)-Bad signaling ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) )
AKT(PKB)-Bad signaling ( IL-7 signaling(JAK1 JAK3 STAT5) ) logo
INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011 173 AKT(PKB)-Bad signaling ( IL-7 signaling(JAK1 JAK3 STAT5) )
Drosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling ) logo
INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011 236 Drosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling )
Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) logo
INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011 178 Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram )
VEGF signaling pathway ( VEGF signaling pathway ) logo
INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011 183 VEGF signaling pathway ( VEGF signaling pathway )
Hedgehog logo
NetPath 12/2011 39 Hedgehog
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants logo
Reactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017 58 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants logo
Reactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017 58 Constitutive Signaling by NOTCH1 PEST Domain Mutants
Generic Transcription Pathway logo
Reactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017 358 Generic Transcription Pathway
NOTCH1 Intracellular Domain Regulates Transcription logo
Reactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017 47 NOTCH1 Intracellular Domain Regulates Transcription