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PIP4K2A (Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha)
FEATURES
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DESCRIPTION
Also known as PI42A_HUMAN, PIP4K2A, PIP5K2, PIP5K2A. Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size. Homodimer (By similarity). Interacts with PIP4K2B. Interaction with PIP4K2B may regulate localization to the nucleus.
Also known as PI42A_HUMAN, PIP4K2A, PIP5K2, PIP5K2A. Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AK ...
PIP4K2A logo

PIP4K2A

Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

3D Viewer

2YBX_B
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