FEATURES

FAMILY

DESCRIPTION

Also known as PF2R_HUMAN, PTGFR. Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost. Isoform 1 can form heterodimers with isoform 5 (and probably other isoforms).

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EXTERNAL LINKS

PTGFR

Prostaglandin F2-alpha receptor

ligandability Mutations

PTGFR

Molecular Synopsis