BMPR1A (Bone morphogenetic protein receptor type-1A)

FEATURES

FAMILY

DESCRIPTION

Also known as BMR1A_HUMAN, BMPR1A, ACVRLK3, ALK3. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. Interacts with BMP2 (PubMed:10881198, PubMed:18937504). Interacts with low affinity with GDF5; positively regulates chondrocyte differentiation (PubMed:24098149).

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EXTERNAL LINKS

BMPR1A

Bone morphogenetic protein receptor type-1A

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

BMPR1A

Molecular Synopsis