TTK (Dual specificity protein kinase TTK)

FEATURES

Loading...

Loading...

FAMILY

Ser/Thr protein kinase family

DESCRIPTION

Also known as TTK_HUMAN, TTK, MPS1, MPS1L1. Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint. Interacts with TPR; the interactions occurs in a microtubule-independent manner.

Also known as TTK_HUMAN, TTK, MPS1, MPS1L1. Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint. Interacts with TPR; the interactions occurs in a mic ...

EXTERNAL LINKS

TTK

Dual specificity protein kinase TTK

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

Molecular Synopsis

LIGANDABILITY

APPROVED DRUGS

No approved drugs found

INVESTIGATIONAL DRUGS

No investigational drugs found

CHEMICAL PROBES

STRUCTURAL LIGANDABILITY

NETWORK-BASED

CANCER SCORE

OTHER DISEASES SCORE

CHEMISTRY-BASED

CHEMISTRY-BASED SCORE