FEATURES

FAMILY

DESCRIPTION

Also known as GBP2_HUMAN, GBP2. Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (PubMed:8706832). Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity). Homodimer; homodimerization occurs upon GTP-binding and is required for the association with membranous structures. Heterodimer with other family members, including GBP1, GBP3, GBP4 and GBP5.

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EXTERNAL LINKS

GBP2

Guanylate-binding protein 2

ligandability Mutations

GBP2

Molecular Synopsis