FEATURES

FAMILY

DESCRIPTION

Also known as GASR_HUMAN, CCKBR, CCKRB. Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system., Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION
PhosphoSitePlus

CCKBR

Gastrin/cholecystokinin type B receptor

ligandability Mutations

CCKBR

Molecular Synopsis