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PRDX2 (Peroxiredoxin-2)
FEATURES
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FAMILY
DESCRIPTION
Also known as PRDX2_HUMAN, PRDX2, NKEFB, TDPX1. Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Homodimer; disulfide-linked, upon oxidation (PubMed:27892488). 5 homodimers assemble to form a ring-like decamer (PubMed:27892488). Interacts with TIPIN (PubMed:17141802).
Also known as PRDX2_HUMAN, PRDX2, NKEFB, TDPX1. Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate ...

Expression

StudyTumor samplesMaxQ3Q2Q1MinNormal samplesMaxQ3Q2Q1MinLog2 (T vs N)
Adrenocortical (ACC) 77 3.26 2.94 2.83 2.75 1.88 126 2.93 2.75 2.68 2.60 -0.09 0.15
Bladder (BLCA) 406 2.84 2.48 2.37 2.25 1.40 9 2.45 2.29 2.18 2.10 2.06 0.19
Breast (BRCA) 1067 2.99 2.44 2.32 2.22 1.39 178 2.55 2.20 2.11 2.05 1.91 0.21
Cervical (CESC) 297 3.27 2.45 2.33 2.24 1.19 10 2.33 2.31 2.16 2.14 2.07 0.18
Cholangiocarcinoma (CHOL) 36 2.98 2.44 2.27 2.18 1.65 0
Colon (COAD) 443 3.24 2.62 2.49 2.38 1.16 166 2.53 2.32 2.25 2.20 -0.09 0.24
B-cell lymphoma (DLBC) 42 2.94 2.42 2.20 2.05 1.58 337 3.82 2.64 2.36 2.11 1.62 -0.16
Esophageal (ESCA) 142 2.49 2.19 2.05 1.94 1.36 271 2.76 2.40 2.33 2.25 -0.09 -0.28
Glioblastoma (GBM) 160 2.97 2.55 2.44 2.35 2.06 214 2.63 2.41 2.36 2.32 -0.09 0.07
Head and neck (HNSC) 432 2.94 2.39 2.25 2.10 1.32 55 2.44 2.26 2.18 2.12 1.95 0.07