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PRDX2 (Peroxiredoxin-2)
FEATURES
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FAMILY
DESCRIPTION
Also known as PRDX2_HUMAN, PRDX2, NKEFB, TDPX1. Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Homodimer; disulfide-linked, upon oxidation (PubMed:27892488). 5 homodimers assemble to form a ring-like decamer (PubMed:27892488). Interacts with TIPIN (PubMed:17141802).
Also known as PRDX2_HUMAN, PRDX2, NKEFB, TDPX1. Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate ...
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PRDX2

Peroxiredoxin-2

Copy number variation

DiseaseSignal Cell linesGain Cell linesAvg. ampLoss Cell linesAvg. lossNo-signal Cell linesAvg. change
cancer 0 0 0 147 0.96
NS 0 0 0 153 0.96
carcinoma 1 1 2.00 0 551 0.96
haematopoietic_neoplasm 0 0 0 63 1.06
leukaemia 0 0 0 84 1.04
lymphoid_neoplasm 0 0 0 135 1.05
glioma 0 0 0 52 1.05
malignant_melanoma 0 0 0 56 1.01
melanoma 0 0 0 43 1.02
glioblastoma 0 0 0 2 1.11

Cell lines

Cell lineSignalCopy numberAvg. genome ploidyAmplificationDiseaseTissue
22Rv-1 No signal 2 2.04 0.98 cancer, NS, carcinoma prostate
5637 No signal 3 2.99 1.00 cancer, carcinoma bladder, urinary_tract
639-V No signal 3 2.41 1.25 cancer, carcinoma bladder, ureter, urinary_tract
647-V No signal 2 2.50 0.80 cancer, carcinoma bladder, urinary_tract
697 No signal 2 1.98 1.01 haematopoietic_neoplasm, leukaemia, lymphoid_neoplasm blood_bone_marrow, haematopoietic_and_lymphoid_tissue
769-P No signal 2 1.97 1.02 carcinoma kidney
786-0 No signal 4 3.82 1.05 cancer, carcinoma kidney
8-MG-BA No signal 2 2.20 0.91 glioma brain, central_nervous_system
8305C No signal 3 3.09 0.97 carcinoma thyroid
8505C No signal 3 3.00 1.00 carcinoma thyroid