FEATURES

FAMILY

DESCRIPTION

Also known as NTR1_HUMAN, NTSR1, NTRR. G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:8381365, PubMed:21725197, PubMed:23140271). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (PubMed:21725197). Interacts (palmitoylated form) with GNA11.

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION
PhosphoSitePlus

NTSR1

Neurotensin receptor type 1

ligandability Mutations

NTSR1

Molecular Synopsis