P/V (Non-structural protein V)

FEATURES

FAMILY

DESCRIPTION

Also known as V_MUMPE, P/V. Plays an essential role in the inhibition of host immune response. Prevents the establishment of cellular antiviral state by blocking interferon-alpha/beta (IFN-alpha/beta) production and signaling pathway. Interacts with host IFIH1/MDA5 and DHX58/LGP2 to inhibit the transduction pathway involved in the activation of IFN-beta promoter, thus protecting the virus against cell antiviral state. Blocks the type I and II interferon signaling pathways by interacting with host STAT1, STAT2 and STAT3, and mediating their ubiquitination and subsequent proteasomal degradation (By similarity). Interacts with host IFIH1/MDA5 and DHX58/LGP2. Forms with host DDB1, CUL4A, STAT1, STAT2 and STAT3 the mumps virus V-dependent complex (VDC) (By similarity).

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EXTERNAL LINKS

P/V

Non-structural protein V

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

P/V

Molecular Synopsis